How Much Do You Need SAM-e?

Always discuss with your physician whether SAM-e is right for you. If you get the go-ahead, it typically is recommended that you start with 200 to 400 milligrams a day and up the dosage by 200 milligrams if you don’t see results within two weeks. Some studies have used up to 1,200 to 1,600 milligrams a day. Look for brands that list 1,4-Butanedisul-fonate on the label. That’s an ingredient in the patented formulation of SAM-e used in Europe. Also look for products that enteric-coated, which ensures they remain intact through the stomach and don’t dissolve until they get into the small intestine, where they are absorbed into the bloodstream.